Spino-cerebellar ataxias
Ataxias are characterized by dysmetria, a hallmark manifestation of cerebellar dysfunction, involving impaired scaling, timing, and coordination of movement. Although dysmetria has been studied in the motor domain, recent theoretical and clinical work suggests that similar coordination deficits extend to cognition, giving rise to the concept of cognitive dysmetria. This project explores whole-brain structural alterations in a mixed sample of spino-cerebellar ataxias, as well as cerebellar functional connectivity, against neurocognitive symptoms and performance in different domains.
Principal Investigators: Dr. Anders Rasmussen (LU); Dr. Maurizio Cundari (LU). LEaP Lab members: Gaia Olivo, Christoffer Olsson.
Project Updates
2026.11.05. Preliminary data presented at the annual 7T User Meeting at LBIC. Data collection still underway.